Pharmacokinetic Modeling of [18F]MC225 for Quantification of the P-Glycoprotein Function at the Blood–Brain Barrier in Non-Human Primates with PET-Reference-Cited by-同舟云学术

Pharmacokinetic Modeling of [18F]MC225 for Quantification of the P-Glycoprotein Function at the Blood–Brain Barrier in Non-Human Primates with PET

Published:2020-08-05 Issue:9 Volume:17 Page:3477-3486
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

García-Varela Lara¹^ORCID,Arif Wejdan M.¹²,Vállez García David¹,Kakiuchi Takeharu³,Ohba Hiroyuki³,Harada Norihiro³,Tago Tetsuro⁴,Elsinga Philip H.¹,Tsukada Hideo³,Colabufo Nicola Antonio⁵⁶^ORCID,Dierckx Rudi A. J. O.¹,van Waarde Aren¹,Toyohara Jun⁴,Boellaard Ronald¹,Luurtsema Gert¹

Affiliation:

1. Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Hanzeplein 1, P.O. Box 30001, Groningen 9713 GZ, the Netherlands

2. Department of Radiological Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia

3. Central Research Laboratory, Hamamatsu Photonics KK, 5000 Hirakuchi, Hamakita, Hamamatsu, Shizuoka 434-8601, Japan

4. Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan

5. Department of Pharmacy, University of Bari Aldo Moro, Bari 70121, Italy

6. Biofordrug, Spin-off Università degli Studi di Bari “A. Moro”, via Dante 99, Triggiano, Bari 70019, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.0c00514

Reference44 articles.

1. Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases

2. The blood–brain barrier: an overview

3. The Functional Role of P-Glycoprotein in the Blood–Brain Barrier

4. Structure and function of the blood–brain barrier

5. Development of the blood-brain barrier

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