Ocular Pharmacokinetics of Therapeutic Antibodies Given by Intravitreal Injection: Estimation of Retinal Permeabilities Using a 3-Compartment Semi-Mechanistic Model-Reference-Cited by-同舟云学术

Ocular Pharmacokinetics of Therapeutic Antibodies Given by Intravitreal Injection: Estimation of Retinal Permeabilities Using a 3-Compartment Semi-Mechanistic Model

Published:2017-07-03 Issue:8 Volume:14 Page:2690-2696
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Hutton-Smith Laurence A.¹,Gaffney Eamonn A.¹,Byrne Helen M.¹,Maini Philip K.¹,Gadkar Kapil²,Mazer Norman A.³^ORCID

Affiliation:

1. Wolfson Centre For Mathematical Biology, Mathematical Institute, Andrew Wiles Building, University of Oxford, Radcliffe Observatory Quarter, Woodstock Road, Oxford OX2 6GG, U.K.

2. Department of Preclinical and Translational Pharmacokinetics, Genentech, Inc., South San Francisco, California 94080, United States

3. Clinical Pharmacology, Roche Pharma Research Early Development, Roche Innovation Center Basel, Bldg. 663/2130.12, Hochstrasse 16, 4070 Basel, Switzerland

Funder

Engineering and Physical Sciences Research Council

Medical Research Council

Roche

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.7b00164

Reference22 articles.

1. Barrier analysis of periocular drug delivery to the posterior segment