Use of Gastrointestinal Simulator, Mass Transport Analysis, and Absorption Simulation to Investigate the Impact of pH Modifiers in Mitigating Weakly Basic Drugs’ Performance Issues Related to Gastric pH: Palbociclib Case Study-Reference-Cited by-同舟云学术

Use of Gastrointestinal Simulator, Mass Transport Analysis, and Absorption Simulation to Investigate the Impact of pH Modifiers in Mitigating Weakly Basic Drugs’ Performance Issues Related to Gastric pH: Palbociclib Case Study

Published:2022-11-11 Issue:1 Volume:20 Page:147-158
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Kuminek Gislaine¹²^ORCID,Salehi Niloufar²³^ORCID,Waltz Nicholas M.²⁴^ORCID,Sperry David C.¹,Greenwood Dale E.¹,Hate Siddhi S.¹,Amidon Gregory E.²^ORCID

Affiliation:

1. Synthetic Molecule Design & Development, Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, Indiana46285, United States

2. Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan48109, United States

3. Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan48109, United States

4. College of Pharmacy, Ohio State University, Columbus, Ohio43210, United States

Funder

Eli Lilly and Company

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.2c00545

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