Structure-Based Discovery of Small-Molecule Inhibitors of the Autocatalytic Proliferation of α-Synuclein Aggregates-Reference-Cited by-同舟云学术

Structure-Based Discovery of Small-Molecule Inhibitors of the Autocatalytic Proliferation of α-Synuclein Aggregates

Published:2022-11-14 Issue:1 Volume:20 Page:183-193
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Chia Sean¹,Faidon Brotzakis Z.¹,Horne Robert I.¹,Possenti Andrea¹,Mannini Benedetta¹^ORCID,Cataldi Rodrigo¹,Nowinska Magdalena¹,Staats Roxine¹,Linse Sara²^ORCID,Knowles Tuomas P. J.¹³^ORCID,Habchi Johnny¹,Vendruscolo Michele¹^ORCID

Affiliation:

1. Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, CambridgeCB2 1EW, U.K.

2. Department of Biochemistry & Structural Biology, Center for Molecular Protein Science, Lund University, 221 00Lund, Sweden

3. Department of Physics, Cavendish Laboratory, CambridgeCB3 0HE, U.K.

Funder

Agency for Science, Technology and Research

Wellcome Trust

Frances and Augustus Newman Foundation

Biotechnology and Biological Sciences Research Council

Department of Chemistry and the Centre for Misfolding Diseases, University of Cambridge

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.2c00548

Reference50 articles.

1. Parkinson disease

2. Global, regional, and national burden of Alzheimer's disease and other dementias, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

3. Parkinson disease

4. The prevalence of Parkinson's disease: A systematic review and meta-analysis

5. α-Synuclein in Lewy bodies

Cited by 18 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Simulating the anti-aggregative effect of fasudil in early dimerisation process of α-synuclein;Biophysical Chemistry;2024-11

2. Pharmacological inhibition of α-synuclein aggregation within liquid condensates;Nature Communications;2024-05-07

3. Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning;Nature Chemical Biology;2024-04-17

4. Ultrastructures of α-Synuclein Filaments in Synucleinopathy Brains and Experimental Models;Journal of Movement Disorders;2024-01-31

5. Using Generative Modeling to Endow with Potency Initially Inert Compounds with Good Bioavailability and Low Toxicity;Journal of Chemical Information and Modeling;2024-01-23