An Investigation into the In Vitro Targeted Killing of CD44-Expressing Triple-Negative Breast Cancer Cells Using Recombinant Photoimmunotherapeutics Compared to Auristatin-F-Based Antibody-Drug Conjugates

Author:

Mungra Neelakshi12,Nsole Biteghe Fleury A.3ORCID,Huysamen Allan M.4ORCID,Hardcastle Natasha S.1,Bunjun Rubina56,Naran Krupa1,Lang Dirk7,Richter Wolfgang8,Hunter Roger4ORCID,Barth Stefan19ORCID

Affiliation:

1. Institute of Infectious Disease and Molecular Medicine, Medical Biotechnology and Immunotherapy Research Unit, University of Cape Town, Cape Town 7700, South Africa

2. Centre for Immunity and Immunotherapies, Seattle Children’s Research Institute, Seattle, Washington 98101, United States

3. College of Science, Department of Biotechnology, Northeastern University, Boston, Massachusetts 02115, United States

4. Department of Chemistry, University of Cape Town, PD Hahn Building, Cape Town 7700, South Africa

5. Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town 7700, South Africa

6. Division of Medical Virology, Department of Pathology, University of Cape Town, Cape Town 7700, South Africa

7. Division of Physiological Sciences, Department of Human Biology, University of Cape Town, Cape Town 7700, South Africa

8. TUBE Pharmaceuticals, Wien 1110, Austria

9. Faculty of Health Sciences, Department of Integrative Biomedical Sciences, South African Research Chair in Cancer Biotechnology, University of Cape Town, Cape Town 7700, South Africa

Funder

National Research Foundation

Department of Science and Innovation, South Africa

South African Medical Research Council

Publisher

American Chemical Society (ACS)

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