Application of a Salt Coformer in a Co-Amorphous Drug System Dramatically Enhances the Glass Transition Temperature: A Case Study of the Ternary System Carbamazepine, Citric Acid, and l-Arginine-Reference-Cited by-同舟云学术

Application of a Salt Coformer in a Co-Amorphous Drug System Dramatically Enhances the Glass Transition Temperature: A Case Study of the Ternary System Carbamazepine, Citric Acid, and l-Arginine

Published:2018-04-09 Issue:5 Volume:15 Page:2036-2044
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Ueda Hiroshi¹²,Wu Wenqi¹,Löbmann Korbinian¹,Grohganz Holger¹^ORCID,Müllertz Anette¹^ORCID,Rades Thomas¹^ORCID

Affiliation:

1. Department of Pharmacy, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark

2. Research Laboratory for Development, Shionogi & Co., Ltd., Osaka 541-0045, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.8b00174

Reference34 articles.

1. Strategies to Address Low Drug Solubility in Discovery and Development

2. Pharmaceutical applications of cyclodextrins: basic science and product development

3. Physical chemistry of supersaturated solutions and implications for oral absorption

4. Prediction of Solubility and Permeability Class Membership: Provisional BCS Classification of the World’s Top Oral Drugs

5. Current trends and future perspectives of solid dispersions containing poorly water-soluble drugs

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