In Vitro Blood–Brain Barrier Permeability and Cytotoxicity of an Atorvastatin-Loaded Nanoformulation Against Glioblastoma in 2D and 3D Models

Author:

Lübtow Michael M.1,Oerter Sabrina2,Quader Sabina3ORCID,Jeanclos Elisabeth45,Cubukova Alevtina6,Krafft Marion2,Haider Malik Salman1,Schulte Clemens1,Meier Laura1,Rist Maximilian1,Sampetrean Oltea7,Kinoh Hiroaki3,Gohla Antje4ORCID,Kataoka Kazunori38,Appelt-Menzel Antje26,Luxenhofer Robert19ORCID

Affiliation:

1. Functional Polymer Materials, Chair for Advanced Materials Synthesis, Department of Chemistry and Pharmacy and Bavarian Polymer Institute, University of Würzburg, Röntgenring 11, 97070 Würzburg, Germany

2. Chair Tissue Engineering and Regenerative Medicine (TERM), University Hospital Würzburg, Röntgenring 11, 97070 Würzburg, Germany

3. Innovation Center of Nanomedicine (iCONM), Kawasaki Institute of Industrial Promotion, 3-25-14 Tonomachi, Kawasaki-Ku, Kawasaki-Shi 210-0821, Japan

4. Institute of Pharmacology and Toxicology, University of Würzburg, Versbacher Straße 9, 97078 Würzburg, Germany

5. Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, Josef-Schneider-Straße 2, 97080 Würzburg, Germany

6. Fraunhofer Institute for Silicate Research ISC, Translational Center Regenerative Therapies TLC-RT, Röntgenring 11, 97070 Würzburg, Germany

7. Institute for Advanced Medical Research (IAMR), Division of Gene Regulation, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan

8. Policy Alternatives Research Institute, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

9. Soft Matter Chemistry, Department of Chemistry, University of Helsinki, 00014 Helsinki, Finland

Funder

Higher Education Commision, Pakistan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

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