Rhizochalinin Exhibits Anticancer Activity and Synergizes with EGFR Inhibitors in Glioblastoma In Vitro Models

Author:

Dyshlovoy Sergey A.12ORCID,Hauschild Jessica1,Venz Simone34,Krisp Christoph5,Kolbe Katharina6,Zapf Svenja6,Heinemann Sarina6,Fita Krystian D.6,Shubina Larisa K.7,Makarieva Tatyana N.7ORCID,Guzii Alla G.7,Rohlfing Tina1,Kaune Moritz1,Busenbender Tobias1,Mair Thomas5,Moritz Manuela5ORCID,Poverennaya Ekaterina V.8ORCID,Schlüter Hartmut5ORCID,Serdyuk Volodymyr9,Stonik Valentin A.7,Dierlamm Judith1,Bokemeyer Carsten1,Mohme Malte6,Westphal Manfred6,Lamszus Katrin6,von Amsberg Gunhild110,Maire Cecile L.6

Affiliation:

1. Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Tumorzentrum − University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg 20251, Germany

2. Laboratory of Biologically Active Compounds, Institute of Science-Intensive Technologies and Advanced Materials, Far Eastern Federal University, Vladivostok 690922, Russian Federation

3. Department of Medical Biochemistry and Molecular Biology, University of Greifswald, Greifswald 17489, Germany

4. Interfacultary Institute of Genetics and Functional Genomics, Department of Functional Genomics, University of Greifswald, Greifswald 17489, Germany

5. Section / Core Facility Mass Spectrometric Proteomics, Center of Diagnostics, University Medical Center Hamburg-Eppendorf, Hamburg 20251, Germany

6. Laboratory for Brain Tumor Research, Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg 20251, Germany

7. G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-East Branch, Russian Academy of Sciences, Vladivostok 690022, Russian Federation

8. Laboratory of Proteoform Interactomics, Institute of Biomedical Chemistry, Moscow 119121, Russian Federation

9. Zentrum für Molekulare Neurobiologie (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg 20251, Germany

10. Martini-Klinik, Prostate Cancer Center, University Hospital Hamburg-Eppendorf, Hamburg 20251, Germany

Funder

Universit??t Hamburg

Deutsche Forschungsgemeinschaft (DFG)

RFBR

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

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