NPP-669, a Novel Broad-Spectrum Antiviral Therapeutic with Excellent Cellular Uptake, Antiviral Potency, Oral Bioavailability, Preclinical Efficacy, and a Promising Safety Margin-Reference-Cited by-同舟云学术

NPP-669, a Novel Broad-Spectrum Antiviral Therapeutic with Excellent Cellular Uptake, Antiviral Potency, Oral Bioavailability, Preclinical Efficacy, and a Promising Safety Margin

Published:2022-12-09 Issue:1 Volume:20 Page:370-382
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Lipka Elke¹,Chadderdon Aaron M.¹,Harteg Cheryl C.¹,Doherty Matthew K.¹^ORCID,Simon Eric S.¹,Domagala John M.¹,Reyna Dawn M.¹,Hutchings Kim M.²,Gan Xinmin²,White Andrew D.²,Hartline Caroll B.³,Harden Emma A.³,Keith Kathy A.³,Prichard Mark N.³,James Scott H.³,Cardin Rhonda D.⁴,Bernstein David I.⁵,Spencer Jacqueline F.⁶,Tollefson Ann E.⁶,Wold William S. M.⁶,Toth Karoly⁶

Affiliation:

1. TSRL, Inc., 540 Avis Dr., Suite A, Ann Arbor, Michigan 48108, United States

2. College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States

3. Department of Pediatrics, University of Alabama School of Medicine, Birmingham, Alabama 35233, United States

4. School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana 70803, United States

5. Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, United States

6. Saint Louis University School of Medicine, St. Louis, Missouri 63104, United States

Funder

National Institute of Allergy and Infectious Diseases

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.2c00668

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3. Co-Infections by Double-Stranded DNA Viruses after Ex Vivo T Cell–Depleted, CD34+ Selected Hematopoietic Cell Transplantation

4. Adenovirus

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