Alleviation of Multiple Asthmatic Pathologic Features with Orally Available and Subtype Selective GABAA Receptor Modulators

Author:

Forkuo Gloria S.1,Nieman Amanda N.1,Yuan Nina Y.1,Kodali Revathi1,Yu Olivia B.1,Zahn Nicolas M.1,Jahan Rajwana1,Li Guanguan1,Stephen Michael Rajesh1ORCID,Guthrie Margaret L.1,Poe Michael M.1,Hartzler Benjamin D.1,Harris Ted W.1,Yocum Gene T.2,Emala Charles W.2,Steeber Douglas A.3,Stafford Douglas C.1,Cook James M.1ORCID,Arnold Leggy A.1ORCID

Affiliation:

1. Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin−Milwaukee, Milwaukee, Wisconsin 53201, United States

2. Department of Anesthesiology, Columbia University, New York, New York 10032, United States

3. Department of Biological Sciences, University of Wisconsin−Milwaukee, Milwaukee, Wisconsin 53201, United States

Funder

Richard and Ethel Herzfeld Foundation

National Institute of Neurological Disorders and Stroke

Foundation for Anesthesia Education and Research

Lynde and Harry Bradley Foundation

National Heart, Lung, and Blood Institute

University of Wisconsin-Milwaukee

National Institute on Drug Abuse

National Institute of Mental Health

National Institute of General Medical Sciences

Stony Wold-Herbert Fund

Research Foundation, University of Wisconsin-Milwaukee

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Reference49 articles.

1. Trends in Asthma Morbidity and Mortality. American Lung Association Epidemiology & Statistics Unit Research and Program Services.

2. National Heart, Lung, and Blood Institute. Guidelines for the Diagnosis and Management of Asthma, Full Report (August 2007) .

3. Airway remodeling contributes to the progressive loss of lung function in asthma: An overview

4. Regular treatment with salmeterol for chronic asthma: serious adverse events

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