Directing Crystallization Outcomes of Conformationally Flexible Molecules: Polymorphs, Solvates, and Desolvation Pathways of Fluconazole-Reference-Cited by-同舟云学术

Directing Crystallization Outcomes of Conformationally Flexible Molecules: Polymorphs, Solvates, and Desolvation Pathways of Fluconazole

Published:2022-01-20 Issue:2 Volume:19 Page:456-471
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Nowak Maciej¹,Dyba Aleksandra J.¹,Janczak Jan²^ORCID,Morritt Alexander³,Fábián László³^ORCID,Karolewicz Bożena¹,Khimyak Yaroslav Z.³^ORCID,Braun Doris E.⁴^ORCID,Nartowski Karol P.¹^ORCID

Affiliation:

1. Department of Drug Form Technology, Wroclaw Medical University, ul. Borowska 211, 50-556 Wroclaw, Poland

2. Institute of Low Temperature and Structure Research, Polish Academy of Sciences, P.O. Box 1410, Okólna 2 str., 50-950 Wroclaw, Poland

3. School of Pharmacy, University of East Anglia, Norwich Research Park, NR4 7TJ Norwich, United Kingdom

4. Institute of Pharmacy, University of Innsbruck, Innrain 52c, 6020 Innsbruck, Austria

Funder

Ministerstwo Nauki i Szkolnictwa Wyzszego

Narodowe Centrum Nauki

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.1c00752

Reference63 articles.

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2. The Importance of Solvates

3. International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human. ICH guideline Q3C (R6) on impurities: guideline for residual solvents. https://database.ich.org/sites/default/files/Q3C-R6_Guideline_ErrorCorrection_2019_0410_0.pdf (accessed May 7, 2021).

4. A Prolific Solvate Former, Galunisertib, under the Pressure of Crystal Structure Prediction, Produces Ten Diverse Polymorphs

5. An approach to solvent screening for crystallization of polymorphic pharmaceuticals and fine chemicals

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