Investigating Crystalline Protein Suspension Formulations of Pembrolizumab from MAS NMR Spectroscopy-Reference-Cited by-同舟云学术

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Investigating Crystalline Protein Suspension Formulations of Pembrolizumab from MAS NMR Spectroscopy

Published:2022-02-02 Issue:3 Volume:19 Page:936-952
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Li Mingyue¹,Reichert Paul²,Narasimhan Chakravarthy³,Sorman Bradley¹,Xu Wei¹,Cote Aaron⁴,Su Yongchao¹^ORCID

Affiliation:

1. Analytical Research and Development, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States

2. Discovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States

3. Pharmaceutical Sciences, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States

4. Biologics Process Research and Development, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.1c00915

Reference159 articles.

1. Monoclonal Antibodies: A Review

2. Challenges in the development of high protein concentration formulations

3. Factors Affecting the Viscosity in High Concentration Solutions of Different Monoclonal Antibodies

4. Crystalline monoclonal antibodies for subcutaneous delivery

5. Protein crystals for the delivery of biopharmaceuticals

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1. Landscape of Subcutaneous Administration Strategies for Monoclonal Antibodies in Oncology;Advanced Materials;2024-08-20

2. Small-Angle X-ray Scattering as a Powerful Tool for Phase and Crystallinity Assessment of Monoclonal Antibody Crystallites in Support of Batch Crystallization;Molecular Pharmaceutics;2024-07-03

3. Stability of Protein Pharmaceuticals: Recent Advances;Pharmaceutical Research;2024-06-27

4. Exploring the Higher Order Structure and Conformational Transitions in Insulin Microcrystalline Biopharmaceuticals by Proton-Detected Solid-State Nuclear Magnetic Resonance at Natural Abundance;Analytical Chemistry;2024-02-08

5. In-situ biophysical characterization of high-concentration protein formulations using w NMR;mAbs;2024-02

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