Design, Synthesis, and Biological Activities of Classical N-{4-[2-(2-Amino-4-ethylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-l-glutamic Acid and Its 6-Methyl Derivative as Potential Dual Inhibitors of Thymidylate Synthase and Dihydrofolate Reductase and as Potential Antitumor Agents-Reference-Cited by-同舟云学术

Design, Synthesis, and Biological Activities of Classical N-{4-[2-(2-Amino-4-ethylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-l-glutamic Acid and Its 6-Methyl Derivative as Potential Dual Inhibitors of Thymidylate Synthase and Dihydrofolate Reductase and as Potential Antitumor Agents

Published:2003-01-21 Issue:4 Volume:46 Page:591-600
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gangjee Aleem¹,Yu Jianming¹,Kisliuk Roy L.¹,Haile William H.¹,Sobrero Giulia¹,McGuire John J.¹

Affiliation:

1. Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282, Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts 02111, and Grace Cancer Drug Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0203534

Reference39 articles.

1. (b) Presented in part at the 223rd National Meeting of the American Chemical Society, Orlando, FL, April 7−11, 2002; Paper MEDI 192.

2. The renewed potential for folate antagonists in contemporary cancer chemotherapy

Cited by 39 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Peptides for Dual Targeting of ErbB1 and ErbB2: Blocking EGFR Cell Signaling Transduction Pathways for Cancer Chemotherapy;Current Molecular Pharmacology;2023-08-10

2. A study of protein–drug interaction based on solvent-induced protein aggregation by fluorescence correlation spectroscopy;The Analyst;2022

3. Progress in Total Syntheses of Anti-malignant Pleural Mesothelioma Compounds;Journal of the Chinese Chemical Society;2018-01-25

4. Dual or multi-targeting inhibitors: The next generation anticancer agents;European Journal of Medicinal Chemistry;2018-01

5. Designing multi-targeted agents: An emerging anticancer drug discovery paradigm;European Journal of Medicinal Chemistry;2017-08