Lead Optimization and Modulation of hERG Activity in a Series of Aminooxazoline Xanthene β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors-Reference-Cited by-同舟云学术

Lead Optimization and Modulation of hERG Activity in a Series of Aminooxazoline Xanthene β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors

Published:2014-11-12 Issue:23 Volume:57 Page:9796-9810
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Epstein Oleg¹,Bryan Marian C.¹,Cheng Alan C.¹,Derakhchan Katayoun¹,Dineen Thomas A.¹,Hickman Dean¹,Hua Zihao¹,Human Jason B.¹,Kreiman Charles¹,Marx Isaac E.¹,Weiss Matthew M.¹,Wahl Robert C.¹,Wen Paul H.¹,Whittington Douglas A.¹,Wood Stephen¹,Zheng Xiao Mei¹,Fremeau Robert T.¹,White Ryan D.¹,Patel Vinod F.¹

Affiliation:

1. Departments of Therapeutic Discovery, ‡Neuroscience, §Molecular Structure and Characterization, ∥Pharmacokinetics and Drug Metabolism, and ⊥Comparative Biology and Safety Sciences, Amgen Inc., 360 Binney Street, Cambridge, Massachusetts 02142, One Amgen Center Drive, Thousand Oaks, California 91320, and 1120 Veterans Boulevard, South San Francisco, California 94080, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm501266w

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