Fragment-Based Design of Symmetrical Bis-benzimidazoles as Selective Inhibitors of the Trimethoprim-Resistant, Type II R67 Dihydrofolate Reductase-Reference-Cited by-同舟云学术

Fragment-Based Design of Symmetrical Bis-benzimidazoles as Selective Inhibitors of the Trimethoprim-Resistant, Type II R67 Dihydrofolate Reductase

Published:2012-03-28 Issue:7 Volume:55 Page:3182-3192
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bastien Dominic¹,Ebert Maximilian C. C. J. C.¹,Forge Delphine²,Toulouse Jacynthe¹,Kadnikova Natalia³,Perron Florent²,Mayence Annie⁴,Huang Tien L.⁴,Vanden Eynde Jean Jacques²,Pelletier Joelle N.¹³

Affiliation:

1. Département de Biochimie, Université de Montréal, C.P. 6128, Succ. Centre-ville Montréal, Québec H3C 3J7, Canada

2. Laboratoire de Chimie Organique, Université de Mons-UMONS, 20 Place du Parc, B-7000 Mons, Belgium

3. Département de Chimie, Université de Montréal, C.P. 6128, Succursale Centre-ville Montréal, Québec H3C 3J7, Canada

4. Division of Basic Pharmaceutical Sciences, Xavier University of Louisiana, 1 Drexel Drive, New Orleans, Louisiana 70125, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm201645r

Reference49 articles.

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4. http://www.who.int/selection_medicines/committees/expert/18/applications/Sulfamethoxazole_trimethoprim.pdf(accessed November 29, 2011) .

5. Trimethoprim resistance in a porcine Pasteurella aerogenes isolate is based on a dfrA1 gene cassette located in a partially truncated class 2 integron

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