The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase: A Conformationally Flexible Pharmacophore-Reference-Cited by-同舟云学术

The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase: A Conformationally Flexible Pharmacophore

Published:2008-07-09 Issue:15 Volume:51 Page:4653-4659
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Xu Hai¹,Fairman James W.¹,Wijerathna Sanath R.¹,Kreischer Nathan R.¹,LaMacchia John¹,Helmbrecht Elizabeth¹,Cooperman Barry S.¹,Dealwis Chris¹

Affiliation:

1. Department of Pharmacology, Case School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106-4965, Department of Biochemistry and Cellular and Molecular Biology, The University of Tennessee, M407 Walters Life Sciences, Knoxville, Tennessee 37996-0840, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm800350u

Reference30 articles.

1. Ribonucleotide reductases: the link between an RNA and a DNA world?

2. Mechanism of Assembly of the Tyrosyl Radical-Dinuclear Iron Cluster Cofactor of Ribonucleotide Reductase

3. Enzymatic Regulation of the Radical Content of the Small Subunit of Escherichia coli Ribonucleotide Reductase Involving Reduction of Its Redox Centers

4. Structures of the Yeast Ribonucleotide Reductase Rnr2 and Rnr4 Homodimers,

5. Inactivation of Ribonucleotide Reductase by (E)-2‘-Fluoromethylene-2‘-deoxycytidine 5‘-Diphosphate: A Paradigm for Nucleotide Mechanism-Based Inhibitors

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