Novel, Broad-Spectrum Anticonvulsants Containing a Sulfamide Group: Advancement of N-((Benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into Human Clinical Studies-Reference-Cited by-同舟云学术

Novel, Broad-Spectrum Anticonvulsants Containing a Sulfamide Group: Advancement of N-((Benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into Human Clinical Studies

Published:2009-04-23 Issue:23 Volume:52 Page:7528-7536
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Parker Michael H.¹,Smith-Swintosky Virginia L.¹,McComsey David F.¹,Huang Yifang¹,Brenneman Douglas¹,Klein Brian¹,Malatynska Ewa¹,White H. Steve²,Milewski Michael E.¹,Herb Mark¹,Finley Michael F. A.¹,Liu Yi¹,Lubin Mary Lou¹,Qin Ning¹,Iannucci Robert³,Leclercq Laurent⁴,Cuyckens Filip⁴,Reitz Allen B.¹,Maryanoff Bruce E.¹

Affiliation:

1. Research and Early Development, Johnson & Johnson Pharmaceutical Research & Development, Spring House, Pennsylvania 19477-0776

2. Department of Pharmacology & Toxicology, College of Pharmacy, University of Utah Health Sciences Center, Salt Lake City, Utah 84112-5820

3. Drug Metabolism and Pharmacokinetics, Johnson & Johnson Pharmaceutical Research & Development, Raritan, New Jersey 08869-0602

4. Drug Metabolism and Pharmacokinetics, Johnson & Johnson Pharmaceutical Research & Development, 2340 Beerse, Belgium

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm801432r

Reference69 articles.

1. Anticonvulsant O-alkyl sulfamates. 2,3:4,5-Bis-O-(1-methylethylidene)-.beta.-D-fructopyranose sulfamate and related compounds

2. Topiramate: Preclinical Evaluation of a Structurally Novel Anticonvulsant

3. TOPIRAMATE < Rec INN; USAN >

4. TOPAMAX (topiramate) had sales of approximately $2 billion/year in 2006, as indicated in the 2006 Johnson & Johnson Annual Report (http://www.jnj.com/news/jnj_news/pdf/kp0604q9l4c3e2.pdf; accessed in Aug 2007) .

5. aThis information is based on various published reports and should not be construed as an attempt to promote the product for these therapeutic uses.

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