Pen-2 Is Essential for γ-Secretase Complex Stability and Trafficking but Partially Dispensable for Endoproteolysis
Author:
Affiliation:
1. Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, United States
Funder
National Institutes of Health
Publisher
American Chemical Society (ACS)
Subject
Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/bi500489j
Reference50 articles.
1. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity
2. -Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2
3. Reconstitution of γ-secretase activity
4. The role of presenilin cofactors in the γ-secretase complex
5. Regulated Intramembrane Proteolysis
Cited by 21 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Functional and topological analysis of PSENEN, the fourth subunit of the γ-secretase complex;Journal of Biological Chemistry;2024-01
2. Evaluation of PEN2-ATP6AP1 axis as an antiparasitic target for metformin based on phylogeny analysis and molecular docking;Molecular and Biochemical Parasitology;2023-09
3. Functional and topological analysis of PSENEN, the fourth subunit of the γ-secretase complex;2023-07-28
4. Metformin: update on mechanisms of action and repurposing potential;Nature Reviews Endocrinology;2023-05-02
5. Converging roles of PSENEN/PEN2 and CLN3 in the autophagy-lysosome system;Autophagy;2021-12-29
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3