1. Pharmaceutical Research Division, Takeda Chemical Industries, Ltd., 10 Wadai, Tsukuba, Ibaraki 300-4293, Japan, Pharmaceutical Research Division, Takeda Chemical Industries, Ltd., 17-85, Jusohonmachi 2-chome, Yodogawa-ku, Osaka 532-8686, Japan, and Strategic Product Planning Department, Takeda Chemical Industries, Ltd., 1-1, Doshomachi 4-chome, Chuo-ku, Osaka 540-8645, Japan