Synthesis of a Parkinson’s Disease Treatment Drug, the R,R-Tartrate Salt of R-Rasagiline: A Three Week Introductory Organic Chemistry Lab Sequence
Author:
Affiliation:
1. Department of Chemistry, University of Texas Permian Basin, 4901 East University, Odessa, Texas 79762, United States
2. Atlanta Metropolitan College, 1630 Metropolitan Parkway Southwest, Atlanta, Georgia 30310, United States
Funder
Welch Foundation
Publisher
American Chemical Society (ACS)
Subject
Education,General Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jchemed.5b00357
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3. (R)(+)-N-Propargyl-1-aminoindan (rasagiline) and derivatives: highly selective and potent inhibitors of monoamine oxidase B
4. Increased striatal dopamine production from L-DOPA following selective inhibition of monoamine oxidase B by R(+)-N-propargyl-1-aminoindan (rasagiline) in the monkey
5. Rasagiline [N-propargyl-1R(+)-aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B
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