Synthesis of a Substance P Antagonist with a Somatostatin Scaffold: Factors Affecting Agonism/Antagonism at GPCRs and the Role of Pseudosymmetry-Reference-Cited by-同舟云学术

Synthesis of a Substance P Antagonist with a Somatostatin Scaffold: Factors Affecting Agonism/Antagonism at GPCRs and the Role of Pseudosymmetry

Published:2000-09-29 Issue:21 Volume:43 Page:3827-3831
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Liu Josephine¹,Underwood Dennis J.¹,Cascieri Margaret A.¹,Rohrer Susan P.¹,Cantin Louis-David¹,Chicchi Gary¹,Smith Amos B.¹,Hirschmann Ralph¹

Affiliation:

1. Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, DuPont Pharmaceutical Company, Wilmington, Delaware 19880, and Merck Research Laboratories, Rahway, New Jersey 07065

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm000316h

Reference48 articles.

1. Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone

2. Somatostatin. Total solid phase synthesis

3. A potent cyclic hexapeptide analogue of somatostatin

4. Variability of the duration of inhibition of growth hormone release by Nα-acylated-des-[Ala1-Gly2]-H2somatostatin analogs

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