Synthesis and Biological Evaluation of New Nanomolar Competitive Inhibitors of Helicobacter pylori Type II Dehydroquinase. Structural Details of the Role of the Aromatic Moieties with Essential Residues-Reference-Cited by-同舟云学术

Synthesis and Biological Evaluation of New Nanomolar Competitive Inhibitors of Helicobacter pylori Type II Dehydroquinase. Structural Details of the Role of the Aromatic Moieties with Essential Residues

Published:2009-11-13 Issue:1 Volume:53 Page:191-200
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Prazeres Verónica F. V.¹,Tizón Lorena¹,Otero José M.²,Guardado-Calvo Pablo²,Llamas-Saiz Antonio L.³,van Raaij Mark J.²⁴,Castedo Luis¹,Lamb Heather⁵,Hawkins Alastair R.⁵,González-Bello Concepción¹

Affiliation:

1. Laboratorio de Química Orgánica (CSIC) y Departamento de Química Orgánica, Facultad de Química, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain

2. Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain

3. Unidad de Rayos X, Edificio CACTUS, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain

4. Instituto de Biología Molecular de Barcelona, Consejo Superior de Investigaciones Científicas (IBMB-CSIC), Parc Científic de Barcelona, Baldiri Reixach 10-12, E-08028 Barcelona, Spain

5. Institute of Cell and Molecular Biosciences, Medical School, University, Newcastle upon Tyne, Catherine Cookson Building, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9010466

Reference53 articles.

1. Antibiotic-Resistant Bugs in the 21st Century — A Clinical Super-Challenge

2. Bacterial persistence: some new insights into an old phenomenon

3. Treatment options for multidrug-resistant bacteria

4. Recently approved and investigational antibiotics for treatment of severe infections caused by Gram-positive bacteria

5. Antimicrobial resistance in developing countries. Part II: strategies for containment

Cited by 21 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Simulation- and AI-directed optimization of 4,6-substituted 1,3,5-triazin-2(1H)-ones as inhibitors of human DNA topoisomerase IIα;Computational and Structural Biotechnology Journal;2024-12

2. A review on the structures and biological activities of anti-Helicobacter pylori agents;European Journal of Medicinal Chemistry;2021-11

3. Flavodoxins as Novel Therapeutic Targets against Helicobacter pylori and Other Gastric Pathogens;International Journal of Molecular Sciences;2020-03-10

4. In silico probing exercises, bioactive-conformational and dynamic simulations strategies for designing and promoting selective therapeutics against Helicobacter pylori strains;Journal of Molecular Graphics and Modelling;2019-11

5. Recently developed synthetic compounds with anti-infective activity;Current Opinion in Pharmacology;2019-10