Selective Continuous Flow Iodination Guided by Direct Spectroscopic Observation of Equilibrating Aryl Lithium Regioisomers

Author:

Dunn Anna L.1ORCID,Leitch David C.1ORCID,Journet Michel1,Martin Michael2,Tabet Elie A.2,Curtis Neil R.3,Williams Glynn3,Goss Charles4,Shaw Tony1,O’Hare Bernie5,Wade Charles3,Toczko Matthew A.2,Liu Peng1

Affiliation:

1. API Chemistry, GlaxoSmithKline, King of Prussia, Pennsylvania 19406, United States

2. Early Development Sciences, GlaxoSmithKline, Research Triangle Park, North Carolina 27709, United States

3. API Chemistry, GlaxoSmithKline, Stevenage, U.K. SG1 2NY

4. Process Analytical Technologies, GlaxoSmithKline, King of Prussia, Pennsylvania 19406, United States

5. Global Spectroscopy, GlaxoSmithKline, King of Prussia, Pennsylvania 19406, United States

Publisher

American Chemical Society (ACS)

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry

Cited by 6 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Continuous Flow Chemistry with Solids: A Review;Organic Process Research & Development;2024-03-14

2. Continuous, stable, and safe organometallic reactions in flow at room temperature assisted by deep eutectic solvents;Chem;2022-12

3. Rapid “high” temperature batch and flow lithiation-trapping of N-Boc pyrrolidine;Tetrahedron;2021-02

4. Organometallic Synthesis in Flow;Reference Module in Chemistry, Molecular Sciences and Chemical Engineering;2021

5. Organolithium Bases in Flow Chemistry: A Review;Organic Process Research & Development;2020-04-30

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