Novel, Highly Potent Aldose Reductase Inhibitors: (R)-(−)-2-(4-Bromo-2-fluorobenzyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine- 4-spiro-3‘-pyrrolidine-1,2‘,3,5‘-tetrone (AS-3201) and Its Congeners-Reference-Cited by-同舟云学术

Novel, Highly Potent Aldose Reductase Inhibitors: (R)-(−)-2-(4-Bromo-2-fluorobenzyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine- 4-spiro-3‘-pyrrolidine-1,2‘,3,5‘-tetrone (AS-3201) and Its Congeners

Published:1998-09-12 Issue:21 Volume:41 Page:4118-4129
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Negoro Toshiyuki¹,Murata Makoto¹,Ueda Shozo¹,Fujitani Buichi¹,Ono Yoshiyuki¹,Kuromiya Akemi¹,Komiya Masanobu¹,Suzuki Kenji¹,Matsumoto Jun-ichi¹

Affiliation:

1. Department of Chemistry I, Discovery Research Laboratories I, Dainippon Pharmaceutical Company, Ltd., Enoki 33-94, Suita/Osaka 564-0053, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9802968

Reference33 articles.

1. Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications

2. N-[[5-(Trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]-N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor

3. Syntheses of tolrestat analogs containing additional substituents in the ring and their evaluation as aldose reductase inhibitors. Identification of potent, orally active 2-fluoro derivatives

4. The effects of a new aldose reductase inhibitor (tolrestat) in galactosemic and diabetic rats

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