Discovery of (2E)-3-{2-Butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an Orally Active Histone Deacetylase Inhibitor with a Superior Preclinical Profile-Reference-Cited by-同舟云学术

Discovery of (2E)-3-{2-Butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an Orally Active Histone Deacetylase Inhibitor with a Superior Preclinical Profile

Published:2011-06-16 Issue:13 Volume:54 Page:4694-4720
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wang Haishan¹,Yu Niefang¹,Chen Dizhong¹,Lee Ken Chi Lik¹,Lye Pek Ling¹,Chang Joyce Wei Wei¹,Deng Weiping¹,Ng Melvin Chi Yeh¹,Lu Ting¹,Khoo Mui Ling¹,Poulsen Anders¹,Sangthongpitag Kanda¹,Wu Xiaofeng¹,Hu Changyong¹,Goh Kee Chuan¹,Wang Xukun¹,Fang Lijuan¹,Goh Kay Lin¹,Khng Hwee Hoon¹,Goh Siok Kun¹,Yeo Pauline¹,Liu Xin¹,Bonday Zahid¹,Wood Jeanette M.¹,Dymock Brian W.¹,Kantharaj Ethirajulu¹,Sun Eric T.¹

Affiliation:

1. Chemistry Discovery, ‡Biology Discovery, and §Pre-Clinical Development, S*BIO Pte Ltd., 1 Science Park Road, No. 05-09 The Capricorn, Singapore Science Park II, Singapore 117528, Singapore

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm2003552

Reference50 articles.

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