First Scale-Up to Production Scale of a Ring Closing Metathesis Reaction Forming a 15-Membered Macrocycle as a Precursor of an Active Pharmaceutical Ingredient-Reference-Cited by-同舟云学术

First Scale-Up to Production Scale of a Ring Closing Metathesis Reaction Forming a 15-Membered Macrocycle as a Precursor of an Active Pharmaceutical Ingredient

Published:2005-06-16 Issue:4 Volume:9 Page:513-515
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Nicola Thomas¹,Brenner Michael¹,Donsbach Kai¹,Kreye Paul¹

Affiliation:

1. Boehringer Ingelheim Pharma GmbH & Co. KG, Department of Process Development, Binger Str. 173, D-55216 Ingelheim, Germany

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op0580015

Reference8 articles.

1. Han, S.Y.; Chang, S. InHandbook of Metathesis; Grubbs, R. H., Ed.; Wiley-VCH: Weinheim, 2003; Vol. 2, pp 5−127.

2. Structure−Activity Study on a Novel Series of Macrocyclic Inhibitors of the Hepatitis C Virus NS3 Protease Leading to the Discovery of BILN 2061

3. Synthesis of BILN 2061, an HCV NS3 Protease Inhibitor with Proven Antiviral Effect in Humans

4. An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus

5. Donsbach, K.; Ecker, D.; Frutos, R. P.; Gallou, F.; Gutheil, D.; Haddad, N.; Hagenkötter, R.; Kemmer, D.; Kröber, J.; Nicola, T.; Schnaubelt, J.; Schul, M.; Simpson, R. D.; Wei, X.; Winter, E.; Xu, Y.; Yee, N. (Boehringer Ingelheim) PCT Int. Appl. WO 04092203, 2004.

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