2-Aminopurine Flipped into the Active Site of the Adenine-Specific DNA Methyltransferase M.TaqI:  Crystal Structures and Time-Resolved Fluorescence

Author:

Lenz Thomas1,Bonnist Eleanor Y. M.1,Pljevaljčić Goran1,Neely Robert K.1,Dryden David T. F.1,Scheidig Axel J.1,Jones Anita C.1,Weinhold Elmar1

Affiliation:

1. Contribution from the Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, D-52056 Aachen, Germany, School of Chemistry and Collaborative Optical Spectroscopy, Micromanipulation and Imaging Centre, The University of Edinburgh, West Mains Road, Edinburgh EH9 3JJ, UK, The Scripps Research Institute, Department of Molecular Biology (MB19), La Jolla, California 92037, and Department 2.5 Biophysics/Structural Biology, Saarland University, Universitätsklinikum, Geb. 60, D-66421 Homburg/Saar,...

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Reference71 articles.

1. Beyond Watson and Crick: DNA Methylation and Molecular Enzymology of DNA Methyltransferases

2. Faumann, E. B.; Blumenthal, R. M.; Cheng X. InS-Adenosylmethionine-dependent methyltransferases:  Structures andfunctions; Cheng, X., Blumenthal, R. M., Eds.; World Scientific Publishing:  Singapore, 1999; pp 1−38.

3. AdoMet-dependent methylation, DNA methyltransferases and base flipping

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