1. Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan, CREST, Japan Science and Technology, Japan, and Graduate School of Engineering, Osaka City University, Sugimoto-3-3-138, Sumiyoshi-ku, Osaka 558-8585, Japan, and Faculty of Medical Sciences, Kyushu University, Maidashi-3-1-1, Higashi-ku, Fukuoka 812-8582, Japan