Discrimination of Potent Inhibitors of Toxoplasma gondii Enoyl-Acyl Carrier Protein Reductase by a Thermal Shift Assay

Author:

Afanador Gustavo A.1,Muench Stephen P.2,McPhillie Martin3,Fomovska Alina4,Schön Arne5,Zhou Ying4,Cheng Gang6,Stec Jozef7,Freundlich Joel S.8,Shieh Hong-Ming9,Anderson John W.9,Jacobus David P.9,Fidock David A.10,Kozikowski Alan P.6,Fishwick Colin W.11,Rice David W.3,Freire Ernesto5,McLeod Rima4,Prigge Sean T.1

Affiliation:

1. Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, United States

2. School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, U.K.

3. Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN U.K.

4. Department of Ophthalmology and Visual Sciences, Pediatrics (Infectious Diseases), Committees on Genetics, Immunology, and Molecular Medicine, Institute of Genomics and Systems Biology, and The College, The University of Chicago, Chicago, Illinois 60612, United States

5. Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, United States

6. Drug Discovery Program, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois 60612, United States

7. College of Pharmacy, Chicago State University, DH 203-3, 9501 South King Drive, Chicago, Illinois 60628, United States

8. Department of Pharmacology and Physiology and Department of Medicine, Center for Emerging and Reemerging Pathogens, Rutgers University-New Jersey Medical School, 185 South Orange Avenue, Newark, New Jersey 07103, United States

9. Department of Medicinal Chemistry, Jacobus Pharmaceutical Company, Princeton, New Jersey 08540, United States

10. Department of Microbiology and Immunology and Division of Infectious Diseases, Department of Medicine, Columbia University Medical Center, New York, New York 10032, United States

11. School of Chemistry, University of Leeds, Leeds LS2 9JT, U.K.

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

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