Design, Synthesis, and Structure−Activity Relationships of Novel Bicyclic Azole-amines as Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5-Reference-Cited by-同舟云学术

Design, Synthesis, and Structure−Activity Relationships of Novel Bicyclic Azole-amines as Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5

Published:2010-09-01 Issue:19 Volume:53 Page:7107-7118
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Burdi Douglas F.¹,Hunt Rachel¹,Fan Lei²,Hu Tao²,Wang Jun²,Guo Zihong²,Huang Zhiqiang²,Wu Chengde³,Hardy Larry¹,Detheux Michel⁴,Orsini Michael A.¹,Quinton Maria S.¹,Lew Robert¹,Spear Kerry¹

Affiliation:

1. Discovery & Early Clinical Research, Sepracor Inc., 84 Waterford Drive, Marlborough, Massachusetts 01752

2. Shanghai ChemPartner, Building no. 6, 998 Haki Road, Zhangjiang Hi-Tech Park, Pudong New Area, Shanghai 201203, China

3. WuXi AppTec Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, Peoples Republic of China

4. EuroScreen SA, Rue Adrienne Bolland 47, B6041 Gosselies, Belgium

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm100736h

Reference26 articles.

1. Pharmacological agents acting at subtypes of metabotropic glutamate receptors

2. Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

3. Novel approaches to targeting glutamate receptors for the treatment of chronic pain: Review article

4. Keywood, C.; Wakefield, M. ASingle-Blind, Placebo-Controlled, Proof of Concept Study of the Effect of the mGluR5 Negative Allosteric Modulator, ADX10059, on 24 h Esophageal pH and Clinical Symptoms, in Patients with Gastroesophageal Reflux Disease (GERD). Presented at theSixth International Meeting on Metabotropic Glutamate Receptors,Taormina, Sicily-Italy,September 14−19, 2008.

5. Addex Pharmaceuticals Home Page,http://www.addexpharma.com(accessed June 7, 2010) .

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