Structure-Based Design of a Novel Series of Potent, Selective Inhibitors of the Class I Phosphatidylinositol 3-Kinases-Reference-Cited by-同舟云学术

Structure-Based Design of a Novel Series of Potent, Selective Inhibitors of the Class I Phosphatidylinositol 3-Kinases

Published:2012-05-23 Issue:11 Volume:55 Page:5188-5219
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Smith Adrian L.¹²,D’Angelo Noel D.¹²,Bo Yunxin Y.¹²,Booker Shon K.¹²,Cee Victor J.¹²,Herberich Brad¹²,Hong Fang-Tsao¹²,Jackson Claire L. M.¹²,Lanman Brian A.¹²,Liu Longbin¹²,Nishimura Nobuko¹²,Pettus Liping H.¹²,Reed Anthony B.¹²,Tadesse Seifu¹²,Tamayo Nuria A.¹²,Wurz Ryan P.¹²,Yang Kevin¹²,Andrews Kristin L.¹²,Whittington Douglas A.¹²,McCarter John D.¹²,Miguel Tisha San¹²,Zalameda Leeanne¹²,Jiang Jian¹²,Subramanian Raju¹²,Mullady Erin L.¹²,Caenepeel Sean¹²,Freeman Daniel J.¹²,Wang Ling¹²,Zhang Nancy¹²,Wu Tian¹²,Hughes Paul E.¹²,Norman Mark H.¹²

Affiliation:

1. Departments of Medicinal Chemistry, ‡Molecular Structure, ∥Pharmacokinetics and Drug Metabolism, ⊥High-Throughput Screening/Molecular Pharmacology, #Oncology Research, and ×Pharmaceutics, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States

2. Departments of Molecular Structure and ∇High-Throughput Screening/Molecular Pharmacology, Amgen Inc., 360 Binney Street, Cambridge, Massachusetts 02142, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm300184s

Reference48 articles.

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3. PHOSPHOINOSITIDE KINASES

4. Helical domain and kinase domain mutations in p110 of phosphatidylinositol 3-kinase induce gain of function by different mechanisms

5. Cancer-specific mutations in phosphatidylinositol 3-kinase

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