Effect of N9-Methylation and Bridge Atom Variation on the Activity of 5-Substituted 2,4-Diaminopyrrolo[2,3-d]pyrimidines against Dihydrofolate Reductases from Pneumocystis carinii and Toxoplasma gondii1a,b-Reference-Cited by-同舟云学术

Effect of N9-Methylation and Bridge Atom Variation on the Activity of 5-Substituted 2,4-Diaminopyrrolo[2,3-d]pyrimidines against Dihydrofolate Reductases from Pneumocystis carinii and Toxoplasma gondii1a,b

Published:1997-03-01 Issue:7 Volume:40 Page:1173-1177
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gangjee Aleem¹,Mavandadi Farahnaz¹,Queener Sherry F.¹

Affiliation:

1. Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282, and Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm960717q

Reference20 articles.

1. (b) Presented in part at the 210th American Chemical Society National Meeting, Chicago, IL, Aug 20−25, 1995; Abstr. MEDI 211.

2. Activity of antifolates against Pneumocystis carinii dihydrofolate reductase and identification of a potent new agent.

3. Inhibitors of folic acid synthesis in the treatment of experimental Pneumocystis carinii pneumonia

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