Rapid and Sensitive Drug Quantification in Tissue Sections Using Matrix Assisted Laser Desorption Ionization-Ion Mobility-Mass Spectrometry Profiling

Author:

Fresnais Margaux12,Muck Alexander3,Majewsky Marius1,Statz Britta456,Krausert Sonja456,Benzel Julia4,Castel David7,Le Dret Ludivine7,Pfister Stefan45,Haefeli Walter E.1,Burhenne Jürgen1ORCID,Longuespée Rémi1ORCID

Affiliation:

1. Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany

2. German Cancer Consortium (DKTK)-German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

3. Waters GmbH, Helfmann-Park 10, 65760 Eschborn, Germany

4. Hopp Children’s Cancer Center, NCT Heidelberg (KiTZ), Im Neuenheimer Feld 460, 69120 Heidelberg, Germany

5. Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

6. Faculty of Biosciences, Heidelberg University, Grabengasse 1, 69117 Heidelberg, Germany

7. Biomarqueurs prédictifs et nouvelles stratégies thérapeutiques en oncologie, Inserm, Gustave Roussy, Université Paris-Saclay, 114 Rue Edouard Vaillant, 94800 Villejuif, France

Publisher

American Chemical Society (ACS)

Subject

Spectroscopy,Structural Biology

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