Optimization of dropletProbe-Mass Spectrometry for Whole-Body Tissue Distribution Analysis of Drug-Like Molecules
Author:
Affiliation:
1. Department of Pharmacokinetics, Pharmacodynamics & Drug Metabolism (PPDM), Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States
Publisher
American Chemical Society (ACS)
Subject
Spectroscopy,Structural Biology
Link
https://pubs.acs.org/doi/pdf/10.1021/jasms.0c00168
Reference15 articles.
1. Autoradiography, MALDI-MS, and SIMS-MS Imaging in Pharmaceutical Discovery and Development
2. MALDI imaging facilitates new topical drug development process by determining quantitative skin distribution profiles
3. From Whole-body Sections Down to Cellular Level, Multiscale Imaging of Phospholipids by MALDI Mass Spectrometry
4. Label-free MS imaging from drug discovery to preclinical development
5. Liquid Microjunction Surface Sampling Coupled with High-Pressure Liquid Chromatography−Electrospray Ionization-Mass Spectrometry for Analysis of Drugs and Metabolites in Whole-Body Thin Tissue Sections
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1. Mass spectrometry imaging of diclofenac and its metabolites in tissues using nanospray desorption electrospray ionization;Analytica Chimica Acta;2022-11
2. Development and Application of DropletProbe Mass Spectrometry for Examining Biodistribution of Therapeutics;Methods in Molecular Biology;2021-12-14
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