Optimization of Monocarboxylate Transporter 1 Blockers through Analysis and Modulation of Atropisomer Interconversion Properties-Reference-Cited by-同舟云学术

Optimization of Monocarboxylate Transporter 1 Blockers through Analysis and Modulation of Atropisomer Interconversion Properties

Published:2006-12-21 Issue:2 Volume:50 Page:254-263
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Guile Simon D.¹,Bantick John R.¹,Cooper Martin E.¹,Donald David K.¹,Eyssade Christine¹,Ingall Anthony H.¹,Lewis Richard J.¹,Martin Barrie P.¹,Mohammed Rukhsana T.¹,Potter Timothy J.¹,Reynolds Rachel H.¹,St-Gallay Stephen A.¹,Wright Andrew D.¹

Affiliation:

1. Department of Medicinal Chemistry, AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, LE11 5RH, UK, and Department of Physical & Metabolic Science, AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, LE11 5RH, UK

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm060995h

Reference33 articles.

1. Potent blockers of the monocarboxylate transporter MCT1: Novel immunomodulatory compounds

2. Target-Oriented and Diversity-Oriented Organic Synthesis in Drug Discovery

3. Monocarboxylate transporter MCT1 is a target for immunosuppression

4. The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation

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