Synthesis and Cancer Stem Cell-Based Activity of Substituted 5-Morpholino-7H-thieno[3,2-b]pyran-7-ones Designed as Next Generation PI3K Inhibitors-Reference-Cited by-同舟云学术

Synthesis and Cancer Stem Cell-Based Activity of Substituted 5-Morpholino-7H-thieno[3,2-b]pyran-7-ones Designed as Next Generation PI3K Inhibitors

Published:2013-02-27 Issue:5 Volume:56 Page:1922-1939
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Morales Guillermo A.¹²,Garlich Joseph R.³²,Su Jingdong²,Peng Xiaodong²,Newblom Jessica²,Weber Kevin²,Durden Donald L.³⁴

Affiliation:

1. BIO5 Institute (Oro Valley), The University of Arizona, 1580 East Hanley Boulevard, Oro Valley, Arizona 85737, United States

2. Semafore Pharmaceuticals Inc., 8496 Georgetown Road, Indianapolis, Indiana 46268, United States

3. SignalRx Pharmaceuticals, 12545 El Camino Real, Suite C, San Diego, California 92130, United States

4. Department of Pediatrics, UCSD Rady Children’s Hospital, Division of Pediatric Hematology−Oncology, Moores Cancer Center, UC San Diego Health System, La Jolla, California 92123, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm301522m

Reference48 articles.

1. Progress in the Design and Development of Phosphoinositide 3-Kinase (PI3K) Inhibitors for the Treatment of Chronic Diseases

2. PI-3 Kinase-PTEN Signaling Node: An Intercept Point for the Control of Angiogenesis

3. Recent Developments in Anti-Cancer Agents Targeting PI3K, Akt and mTORC1/2

4. Targeting the PI3K/Akt/mTOR Pathway - Beyond Rapalogs

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