Target Guided Synthesis of 5-Benzyl-2,4-diamonopyrimidines: Their Antimalarial Activities and Binding Affinities to Wild Type and Mutant Dihydrofolate Reductases from Plasmodium falciparum-Reference-Cited by-同舟云学术

Target Guided Synthesis of 5-Benzyl-2,4-diamonopyrimidines: Their Antimalarial Activities and Binding Affinities to Wild Type and Mutant Dihydrofolate Reductases from Plasmodium falciparum

Published:2003-12-16 Issue:2 Volume:47 Page:345-354
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sirichaiwat Chawanee¹,Intaraudom Chakapong¹,Kamchonwongpaisan Sumalee¹,Vanichtanankul Jarunee¹,Thebtaranonth Yodhathai¹,Yuthavong Yongyuth¹

Affiliation:

1. National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, 113 Thailand Science Park, Pahonyothin Road, Klong 1, Klongluang, Pathumtani 12120, Thailand, and Department of Chemistry, Faculty of Science, Mahidol Univerity, Rama 6 Road, Bangkok 10400, Thailand

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0303352

Reference26 articles.

1. Drug resistance in malaria

2. Reaching Maturity — 25 Years of the TDR

3. Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria.

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