Discovery of Selective LRRK2 Inhibitors Guided by Computational Analysis and Molecular Modeling-Reference-Cited by-同舟云学术

Discovery of Selective LRRK2 Inhibitors Guided by Computational Analysis and Molecular Modeling

Published:2012-06-01 Issue:11 Volume:55 Page:5536-5545
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chen Huifen¹,Chan Bryan K.¹,Drummond Jason¹,Estrada Anthony A.¹,Gunzner-Toste Janet¹,Liu Xingrong¹,Liu Yichin¹,Moffat John¹,Shore Daniel¹,Sweeney Zachary K.¹,Tran Thuy¹,Wang Shumei¹,Zhao Guiling¹,Zhu Haitao¹,Burdick Daniel J.¹

Affiliation:

1. Discovery Chemistry Department, ‡Biochemical and Cellular Pharmacology Department, §Drug Metabolism and Pharmacokinetics Department, and ∥Neuroscience Department, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm300452p

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1. Parkinson's disease

2. Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology

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