In Silico Discovery of a Compound with Nanomolar Affinity to Antithrombin Causing Partial Activation and Increased Heparin Affinity-Reference-Cited by-同舟云学术

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In Silico Discovery of a Compound with Nanomolar Affinity to Antithrombin Causing Partial Activation and Increased Heparin Affinity

Published:2012-07-17 Issue:14 Volume:55 Page:6403-6412
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Navarro-Fernández J.¹,Pérez-Sánchez H.²³,Martínez-Martínez I.¹,Meliciani I.²,Guerrero J. A.¹,Vicente V.¹,Corral J.¹,Wenzel W.²

Affiliation:

1. Servicio de Hematología y Oncología Médica, H. U. Morales Meseguer, Centro Regional de Hemodonación, University of Murcia, Spain

2. Institute of Nanotechnologie, Karlsruhe Institute of Technology, Karlsruhe, Germany

3. Department of Computer Engineering, School of Computer Science, University of Murcia, Spain

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm300621j

Reference54 articles.

1. New antithrombotic agents—insights from clinical trials

2. Structure of a serpin–protease complex shows inhibition by deformation

3. Formation of the covalent serpin-proteinase complex involves translocation of the proteinase by more than 70 A and full insertion of the reactive center loop into -sheet A

4. Localization of anticoagulantly active heparan sulfate proteoglycans in vascular endothelium: antithrombin binding on cultured endothelial cells and perfused rat aorta.

5. Cloned bovine aortic endothelial cells synthesize anticoagulantly active heparan sulfate proteoglycan.

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