1. Okazaki Institute for Integrative Bioscience, National Institute of Natural Sciences, Okazaki, Aichi 444-8787, Japan, Department of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Kanagawa 226-8501, Japan, and Molecular Gerontology Group, Mitsubishi Kagaku Institute of Life Sciences (MITILS), Machida, Tokyo 194-8511, Japan