Flexible and Scalable Route to HDAc Inhibitors Containing an Unusual Trisubstituted Pyridine Core-Reference-Cited by-同舟云学术

Flexible and Scalable Route to HDAc Inhibitors Containing an Unusual Trisubstituted Pyridine Core

Published:2012-06-27 Issue:7 Volume:16 Page:1283-1292
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Graham Mark A.¹,Raw Steven A.²,Andrews David M.¹,Good Catherine J.³,Matusiak Zbigniew S.¹,Maybury Mark³,Stokes Elaine S. E.¹,Turner Andrew T.³

Affiliation:

1. Oncology Innovative Medicines, AstraZeneca, Mereside, Alderley Park, Macclesfield SK10 4TG, U.K.

2. Medicines Evaluation Chemistry, Pharmaceutical Development, AstraZeneca, Charter Way, Macclesfield SK10 2NA, U.K.

3. Chemical Science, Pharmaceutical Development, AstraZeneca, Charter Way, Macclesfield SK10 2NA, U.K.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op300021m

Reference35 articles.

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3. Optimization of the First Selective Steroid-11β-hydroxylase (CYP11B1) Inhibitors for the Treatment of Cortisol Dependent Diseases

4. Selective antagonists of mouse trace amine-associated receptor 1 (mTAAR1): Discovery of EPPTB (RO5212773)

5. The identification of orally bioavailable thrombopoietin agonists

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