Flexible and Scalable Route to HDAc Inhibitors Containing an Unusual Trisubstituted Pyridine Core

Author:

Graham Mark A.1,Raw Steven A.2,Andrews David M.1,Good Catherine J.3,Matusiak Zbigniew S.1,Maybury Mark3,Stokes Elaine S. E.1,Turner Andrew T.3

Affiliation:

1. Oncology Innovative Medicines, AstraZeneca, Mereside, Alderley Park, Macclesfield SK10 4TG, U.K.

2. Medicines Evaluation Chemistry, Pharmaceutical Development, AstraZeneca, Charter Way, Macclesfield SK10 2NA, U.K.

3. Chemical Science, Pharmaceutical Development, AstraZeneca, Charter Way, Macclesfield SK10 2NA, U.K.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Reference35 articles.

1. Discovery of pyrimidine carboxamides as potent and selective CCK1 receptor agonists

2. bInsecticides:Murata, T.; Yoneta, Y.; Kishikawa, H.; Mihara, J.; Yamazaki, D.; Hatazawa, M.; Sasaki, N.; Domon, K.; Shimojo, E.; Ichihara, T.; Shibuya, K.; Ataka, M.; Görgens, U.Insecticidal Arylpyrrolines. WO 2010/133336;Chem. Abstr. 2010, 153, 618717.

3. Optimization of the First Selective Steroid-11β-hydroxylase (CYP11B1) Inhibitors for the Treatment of Cortisol Dependent Diseases

4. Selective antagonists of mouse trace amine-associated receptor 1 (mTAAR1): Discovery of EPPTB (RO5212773)

5. The identification of orally bioavailable thrombopoietin agonists

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