Structure−Activity Relationships in a Series of Orally Active γ-Hydroxy Butenolide Endothelin Antagonists-Reference-Cited by-同舟云学术

Structure−Activity Relationships in a Series of Orally Active γ-Hydroxy Butenolide Endothelin Antagonists

Published:1997-03-01 Issue:7 Volume:40 Page:1063-1074
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Patt William C.¹,Edmunds Jeremy J.¹,Repine Joseph T.¹,Berryman Kent A.¹,Reisdorph Billy R.¹,Lee Chet¹,Plummer Mark S.¹,Shahripour Aurash¹,Haleen Stephen J.¹,Keiser Joan A.¹,Flynn Mike A.¹,Welch Kathleen M.¹,Reynolds Elwood E.¹,Rubin Ron¹,Tobias Brian¹,Hallak Hussein¹,Doherty Annette M.¹

Affiliation:

1. Departments of Medicinal Chemistry, Cardiovascular Therapeutics, Analytical Research, Pharmacokinetics and Drug Metabolism, and Biomolecular Structure and Drug Design, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, 2800 Plymouth Road, Ann Arbor, Michigan 48105

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9606507

Reference57 articles.

1. A novel potent vasoconstrictor peptide produced by vascular endothelial cells

2. The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

3. Endothelin in myocardial infarction

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