Nondenaturing Size-Exclusion Chromatography-Mass Spectrometry to Measure Stress-Induced Aggregation in a Complex Mixture of Monoclonal Antibodies
Author:
Affiliation:
1. Drug Product Development, Amgen Inc., Seattle, Washington 98119, United States
Publisher
American Chemical Society (ACS)
Subject
Analytical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/ac401455f
Reference20 articles.
1. Protein aggregation and its inhibition in biopharmaceutics
2. Effects of protein aggregates: An immunologic perspective
3. Stability of Protein Pharmaceuticals: An Update
4. Shaken, Not Stirred: Mechanical Stress Testing of an IgG1 Antibody
5. The use of native cation-exchange chromatography to study aggregation and phase separation of monoclonal antibodies
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