Self-Healing Hydrogel Resulting from the Noncovalent Interaction between Ropivacaine and Low-Molecular-Weight Gelator Sodium Deoxycholate Achieves Stable and Endurable Local Analgesia in Vivo

Author:

Tan Xin1ORCID,Zhou Yi2,Qin Yaxin1,Wu Linjie1,Yang Ruizhi3,Bao Xiaoyan1,Jiang Ruolin1ORCID,Sun Xiaoyan1,Ying Xufang1,Ben Zhiqing1,Dai Qi4,Zhang Zhicheng4,Zeng Kai3,Han Min1456ORCID

Affiliation:

1. Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China

2. National Narcotic Laboratory Zhejiang Regional Center, Hangzhou 310000, China

3. Department of Anesthesiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China

4. Department of Radiation Oncology, Key Laboratory of Cancer Prevention and Intervention, The Second Afliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310058, China

5. Hangzhou Institute of Innovative Medicine, Zhejiang University, Hangzhou 310058, PR China

6. National Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang University, Hangzhou 310058, China

Funder

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

Natural Science Foundation of Zhejiang Province

Publisher

American Chemical Society (ACS)

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