Carbodiimide EDC Induces Cross-Links That Stabilize RNase A C-Dimer against Dissociation: EDC Adducts Can Affect Protein Net Charge, Conformation, and Activity

Author:

López-Alonso Jorge P.1,Diez-García Fernando1,Font Josep1,Ribó Marc1,Vilanova Maria1,Scholtz J. Martin1,González Carlos1,Vottariello Francesca1,Gotte Giovanni1,Libonati Massimo1,Laurents Douglas V.1

Affiliation:

1. Instituto de Química Física “Rocasolano” (C.S.I.C.), Serrano 119, E-28006, Madrid, Spain, Dipartimento di Scienze Morfologico-Biomediche, Sezione di Chimica Biologica, Facoltà di Medicina e Chirurgia, Università di Verona, Strada Le Grazie 8, I-37134, Verona, Italy, Laboratori d’Enginyeria de Proteïnes, Departament de Biología, Facultad de Ciències, Universitat de Girona, Campus Montilivi, 17071 Girona, Spain, and Department of Medical Biochemistry, Texas A&M University School of Medicine, College...

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

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