Selective Inhibition of the Kir2 Family of Inward Rectifier Potassium Channels by a Small Molecule Probe: The Discovery, SAR, and Pharmacological Characterization of ML133-Reference-Cited by-同舟云学术

Selective Inhibition of the Kir2 Family of Inward Rectifier Potassium Channels by a Small Molecule Probe: The Discovery, SAR, and Pharmacological Characterization of ML133

Published:2011-06-13 Issue:8 Volume:6 Page:845-856
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Wang Hao-Ran¹,Wu Meng¹,Yu Haibo¹,Long Shunyou¹,Stevens Amy¹,Engers Darren W.²,Sackin Henry³,Daniels J. Scott²,Dawson Eric S.²,Hopkins Corey R.²,Lindsley Craig W.²,Li Min¹,McManus Owen B.¹

Affiliation:

1. Department of Neuroscience, High Throughput Biology Center and Johns Hopkins Ion Channel Center, School of Medicine, Johns Hopkins University, 733 North Broadway, Baltimore, Maryland 21205, United States

2. Vanderbilt Specialized Chemistry Center, Department of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States

3. Department of Physiology and Biophysics, Rosalind Franklin University of Medicine and Science, North Chicago, Ilinois 60064, United States

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/cb200146a

Reference41 articles.

1. Ion Channels and Synaptic Organization

2. Biophysical, pharmacological, and functional characteristics of cloned and native mammalian two-pore domain K+ channels

3. The Structure of the Potassium Channel: Molecular Basis of K + Conduction and Selectivity

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