Method to Differentiate Asn Deamidation That Occurred Prior to and during Sample Preparation of a Monoclonal Antibody
Author:
Affiliation:
1. Process Sciences Department and Chemistry Department, Abbott Bioresearch Center, Worcester, Massachusetts 01605
Publisher
American Chemical Society (ACS)
Subject
Analytical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/ac801617u
Reference28 articles.
1. Heterogeneity of Monoclonal Antibodies
2. Antibody Structure, Instability, and Formulation
3. Deamidation, isomerization, and racemization at asparaginyl and aspartyl residues in peptides. Succinimide-linked reactions that contribute to protein degradation.
4. Nonenzymatic Deamidation of Asparaginyl and Glutaminyl Residues in Protein
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