Design, Synthesis, and Evaluation of a Novel Dual Fms-Like Tyrosine Kinase 3/Stem Cell Factor Receptor (FLT3/c-KIT) Inhibitor for the Treatment of Acute Myelogenous Leukemia-Reference-Cited by-同舟云学术

Design, Synthesis, and Evaluation of a Novel Dual Fms-Like Tyrosine Kinase 3/Stem Cell Factor Receptor (FLT3/c-KIT) Inhibitor for the Treatment of Acute Myelogenous Leukemia

Published:2011-10-04 Issue:20 Volume:54 Page:7184-7192
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Davies Robert J.¹,Pierce Albert C.¹,Forster Cornelia²,Grey Ron¹,Xu Jinwang¹,Arnost Michael¹,Choquette Deborah³,Galullo Vincent⁴,Tian Shi-Kai⁵,Henkel Greg⁶,Chen Guanjing²,Heidary David K.⁷,Ma Joanne⁸,Stuver-Moody Cameron¹,Namchuk Mark¹

Affiliation:

1. Vertex Pharmaceuticals Inc., 130 Waverly Street, Cambridge, Massachusetts 02139, United States

2. Novartis IBMR, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States

3. Amgen, 1 Kendall Square, Cambridge, Massachusetts 02139, United States

4. Astra Zeneca R&D Boston, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States

5. University of Science & Technology of China, Hefei, Anhui 230026, China

6. Arisan Therapeutics, 21512 Canaria, Mission Viejo, California 92692, United States

7. University of Kentucky, Lexington, Kentucky 40506, United States

8. Merck West Point, 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm200712h

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