2-Amino-1,3-thiazol-4(5H)-ones as Potent and Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors: Enzyme−Ligand Co-Crystal Structure and Demonstration of Pharmacodynamic Effects in C57Bl/6 Mice-Reference-Cited by-同舟云学术

2-Amino-1,3-thiazol-4(5H)-ones as Potent and Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors: Enzyme−Ligand Co-Crystal Structure and Demonstration of Pharmacodynamic Effects in C57Bl/6 Mice

Published:2008-04-18 Issue:10 Volume:51 Page:2933-2943
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Johansson Lars¹,Fotsch Christopher¹,Bartberger Michael D.¹,Castro Victor M.¹,Chen Michelle¹,Emery Maurice¹,Gustafsson Sonja¹,Hale Clarence¹,Hickman Dean¹,Homan Evert¹,Jordan Steven R.¹,Komorowski Renee¹,Li Aiwen¹,McRae Kenneth¹,Moniz George¹,Matsumoto Guy¹,Orihuela Carlos¹,Palm Gunnar¹,Veniant Murielle¹,Wang Minghan¹,Williams Meredith¹,Zhang Jiandong¹

Affiliation:

1. Biovitrum AB, SE-112 76 Stockholm, Sweden, and Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm701551j

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