Modeling Cyclooxygenase Inhibition. Implication of Active Site Hydration on the Selectivity of Ketoprofen Analogues-Reference-Cited by-同舟云学术

Modeling Cyclooxygenase Inhibition. Implication of Active Site Hydration on the Selectivity of Ketoprofen Analogues

Published:2000-05-04 Issue:11 Volume:43 Page:2280-2284
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Palomer Albert¹,Pérez Juan J.¹,Navea Susana¹,Llorens Oriol¹,Pascual Jaume¹,García Lluïsa¹,Mauleón David¹

Affiliation:

1. R & D Department, Laboratorios Menarini, Alfonso XII 587, 08918 Badalona, Spain, and Department d'Enginyeria Química, UPC, ETSEIB, Diagonal 647, 08028 Barcelona, Spain

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9906217

Reference26 articles.

1. Inhibition of Prostaglandin Synthetase in Brain explains the Anti-pyretic Activity of Paracetamol (4-Acetamidophenol)

2. Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

3. Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

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